Alzheimer s disease (in German [alt͡shaɪ̯mɐ]) is a neurodegenerative disease (progressive loss of neurons) incurable to date of brain tissue that causes the gradual and irreversible loss of mental functions and in particular memory. This is the most common cause of dementia in humans. It was initially described by the German doctor Alzheimer in 1906.
The first symptom is often losses of memories (amnesia), originally manifested by minor distractions, which are increasing with the progression of the disease. It is first the short-term memory that is affected. Older memories, however, are relatively preserved. Neurological involvement subsequently extends to frontal and temporo-parietal associative cortex, resulting in more severe cognitive disorders (confusions, irritability, aggression, mood disorders and emotions, executive functions and language) and the loss of long-term memory. The destruction of neurons continues until the loss of autonomous functions and death.
Two types of nervous tissue lesions characterize Alzheimer s disease: senile plates (or amyloid deposits) and neurofibrillary degeneration. The constituents of these lesions are respectively the amyloid peptide (or aβ) and the tau protein. The causes of aggregation of these proteins in amyloid deposits and neurofibrillary degeneration are still unknown, but genetic and environmental factors would contribute to their appearance. The first risk factor is age but there are also genetic risk factors (family forms (<1%) with mutations of the precursor of the amyloid peptide or protein genes (presenilines) involved in its genesis), of Cardiovascular risk factors or poisoning by certain heavy metals or drugs.
The diagnosis of Alzheimer s disease is based primarily on interrogation, neuropsychological, psychomotor tests and on the highlighting of cortical atrophy that first affects the internal temporal lobe, including the hippocampus, important regions for the memory. The first signs of Alzheimer s disease are often combined with the normal aspects of senescence, depression, stress or other neurological diseases such as vascular dementia. It was thus under-diagnosed into the 1960s. The diagnosis has improved with biological tests in the cerebrospinal fluid (dosage of tau proteins and amyloid peptide) and neuroimaging (MRI, TEP…). The speed and evolution of the disease vary according to the individual, which makes it difficult to prognostic, including life expectancy (3 to 8 years depending on the age of the patient at the time of diagnosis,).
No treatment is currently cured of this disease. Treatments aim to limit its progression. The care proposed are mainly palliative. Cognitive stimulation, physical exercise and balanced diet could delay the onset of cognitive disorders in the elderly. Because Alzheimer s disease is degenerative, the patient relies on others to help him. The role of the main caregiver is paramount,,. Up to 70% of people suffering from psychological distress, defined by anxiety, depression and insomnia, that can disrupt their daily operation, reduce their quality of life, and accelerate their cognitive decline,.
In 2015, there are approximately 48 million people in the world with Alzheimer s disease. Most often, the disease begins with people above 65 years; Only 4% to 5% of early Alzheimer s cases begin before this age. About 6% of people aged 65 and over are affected, but these numbers differ according to countries. In 2010, dementia caused by the disease caused about 486,000 dead in the world.
In developed countries, it is one of the most expensive diseases for society.
Faced with the prevalence of illness, medical research efforts are aimed at developing drugs capable of stopping the neurodegenerative process. The main tracks are to tackle the amyloid plates for forming between neurons during the disease and aggregates of tau proteins forming neurofibrillary degeneracy inside neurons.
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In this way, and with the premiere on PC just around the corner, Bright Memory: Infinite is prepared to challenge all lovers of fast shooters, something that you can also experience the public of Xbox Series In the future, as we have seen in a Gameplay trailer. An opportunity to return to frantic shots with a proposal of realistic graphics and brutal monsters to which we have already been able to access in the past, as we have it in these Bright Memory impressions: Infinite.